Recombinant high growth rate influenza virus comprising mutations in M1, NS2, and PB2
US12350325B2 · kind B2 · utility
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Key dates
| Filing date | Jan 24, 2020 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Aug 21, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16251
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides high growth influenza reassortant virus and high growth influenza reassortant virus vectors comprising amino acid modifications in the PB2, PB1, M1 and/or NS2 proteins which exhibit highly increased growth rates compared to unmodified influenza virus. Further provided are pharmaceutical compositions comprising reassortant virus and viral vectors comprising said modifications and their use for vaccination purposes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.