Compositions and methods for generating a persisting population of T cells useful for the treatment of cancer
US12350334B2 · kind B2 · utility
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42References
15Claims
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Key dates
| Filing date | May 12, 2021 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Jun 15, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.
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