Viscosity reduction of highly concentrated protein formulations

US12350340B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Martin Zillmann · Billerica, US
• Alexandra KROG · Bodenheim, DE
• Raphael Guebeli · Darmstadt, DE
• Tanja Henzler · Schriesheim, DE
• Christian HILDEBRANDT · Heppenheim, DE

Key dates

• Filing date: Dec 6, 2021
• Grant date: Jul 8, 2025
• Expiry date: Dec 15, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K16/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compositions of highly concentrated protein formulations showing reduced viscosity. The contained proteins in the prepared formulations are stabilized against aggregation and denaturation and are thus sufficiently storage-stable until administration to the patient.