Bicyclic peptide ligands specific for MT1-MMP
US12350343B2 · kind B2 · utility
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72References
17Claims
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Key dates
| Filing date | Dec 13, 2019 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Apr 19, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptides which are covalently bound to non-aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of membrane type 1 metalloprotease (MT1-MMP), such as the collagen binding site of MT1-MMP. The invention also describes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups which have utility in imaging and targeted cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.