Conjugates enhancing total cellular accumulation
US12350346B2 · kind B2 · utility
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5References
14Claims
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Key dates
| Filing date | Jul 12, 2023 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Jul 12, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide production which destabilize endosome-lysosome membrane. The conjugated compound can further comprise payload.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.