Serial filtration to generate small cholesterol-containing liposomes
US12350369B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Dec 14, 2021 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Jun 29, 2043 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D61/58
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods and systems for producing liposomes by filtration. The methods include passing a heated lipid suspension through a filter assembly comprising two or more filters connected in series, wherein an orifice is disposed between adjacent filters. The methods and systems can produce liposomes having an average diameter that is less than half the diameter of the filter pores. Further, the methods and systems can produce liposomes with <100 nm average diameter, even when the liposomes comprise at least 30% sterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.