Process for synthesizing apremilast
US12351555B2 · kind B2 · utility
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Key dates
| Filing date | Apr 25, 2022 |
| Grant date | Jul 8, 2025 |
| Priority date | — |
| Expiry date | Apr 25, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are processes for synthesizing apremilast comprising reacting 3-acetamidophthalic anhydride and (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine or a salt thereof to form apremilast. Also provided are processes for isolating apremilast from the reaction mixture, as described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.