Systems and methods fabricating a microchannel vascular network device and seeding a microchannel

US12351827B2 · kind B2 · utility

Assignee

• 3D BioLabs, Inc. · US

Inventors

• Joseph P. Vacanti · Winchester, US
• Batzaya Byambaa · Cambridge, US
• Carly Comer · Boston, US
• Matthew Hancock · Newton, US
• Tyler Lieberthal · Brookline, US
• Tatevik Sahakyants · Lexington, US
• Andrew Spann · Needham, US
• Craig Neville · Boston, US

Key dates

• Filing date: Jun 18, 2020
• Grant date: Jul 8, 2025
• Expiry date: Sep 4, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/54
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A method of fabricating a microchannel device is provided. The method includes determining, based on a plurality of design criteria, a microchannel vascular network design. The microchannel vascular network design includes a first channel network, a second microchannel network based on the first channel network, and a structure for providing fluidic communication through between the first channel network and the second channel network. The method includes receiving, in electronic form, the microchannel vascular network design at a fabrication system. The fabrication system comprises a pre-polymer solution. The method includes forming, based on the microchannel vascular network design, a microchannel vascular network device of a polymer material at the fabrication system using the pre-polymer solution, thereby fabricating the microchannel vascular network device.