Method for qualitative identification and quantitative determination of caffeine in drug

US12352693B2 · kind B2 · utility

Assignees

• University of Shanghai for Science and Technology · CN
• CHONGQING INSTITUTE FOR FOOD AND DRUG CONTROL · CN

Inventors

• Yan Peng · Shanghai, CN
• Linggao Zeng · Longbeilingcun, CN
• Yiming Zhu · Hefei, CN
• Qingrou Yang · Shanghai, CN
• Chenjun Shi · El Monte, US
• Xu Wu · Shanghai, CN
• Songlin Zhuang · Shanghai, CN

Key dates

• Filing date: Aug 27, 2021
• Grant date: Jul 8, 2025
• Expiry date: Apr 18, 2044

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2021/3595
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method for qualitative identification and quantitative determination of caffeine in a drug. In the method, terahertz absorption coefficient spectra of drugs with different concentrations of caffeine are measured, from which the frequency points, amplitudes and peak areas of characteristic peaks of the drugs with different concentrations of caffeine are obtained as characteristic quantities. Concentration gradients are established between the concentrations and the characteristic quantities, respectively. The characteristic quantities are imported to the SVR model to establish a training set and a test set. Finally, the qualitative identification and quantitative analysis of caffeine in unknown drugs are achieved.