2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy

US12357634B2 · kind B2 · utility

Assignee

• THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING · SE

Inventors

• Christoffer Bengtsson · Bromma, SE
• Sanjay Borhade · Lund, SE
• Martin Haraldsson · Täby, SE
• Thomas Helleday · Stockholm, SE
• Martin Henriksson · Stockholm, SE
• Evert Homan · Sollentuna, SE
• Cynthia Paulin · Stuvsta-Snättringe, SE
• Lars Sandberg · Stockholm, SE
• Martin Scobie · Uppsala, SE
• Pål Erik Gustav Stenmark · Söderhamn, SE
• Karl Sven Axel Vallin · Stockholm, SE

Key dates

• Filing date: Oct 14, 2022
• Grant date: Jul 15, 2025
• Expiry date: Feb 28, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula I or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of cancers, inflammation, autoimmune diseases and graft-versus host diseases (e.g. in transplantation patients). A pharmaceutical composition comprising the compound or its salt and a method for preparing the compound.