Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition

US12357696B2 · kind B2 · utility

Inventors

• Michael Aven · Mainz, DE
• Tim LUKAS · Heidesheim, DE

Key dates

• Filing date: Oct 26, 2021
• Grant date: Jul 15, 2025
• Expiry date: Mar 7, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A preserved liquid aqueous pharmaceutical composition includes one or more etherified cyclodextrin derivatives, at least one water-soluble preservative, and at least one pharmaceutically active compound which is poorly water-soluble, very poorly water-soluble or water-insoluble. The liquid aqueous pharmaceutical composition provides an acceptable solubility of the pharmaceutically active compound, such as pimobendan, in aqueous solution whereby the water-soluble preservatives retain their effectiveness in the presence of the etherified cyclodextrin derivatives allowing the use in an oral administration form.