Highly accurate de novo polynucleotide synthesis
US12357959B2 · kind B2 · utility
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Key dates
| Filing date | Dec 23, 2019 |
| Grant date | Jul 15, 2025 |
| Priority date | — |
| Expiry date | Feb 13, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.