Patent · US Active

CTLA-4 variant immunomodulatory proteins and uses thereof

US12358969B2 · kind B2 · utility

0Cited by

114References

37Claims

0Family size

Assignee

Alpine Immune Sciences, Inc. · US

Inventors

Lawrence Evans · Dorris, US
Joseph L. Kuijper · Kenmore, US
Ryan Swanson · Seattle, US

Key dates

Filing date	Jul 20, 2023
Grant date	Jul 15, 2025
Priority date	—
Expiry date	Jul 26, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.