Neutral fluorescent mitochondrial marker as amide derivative, and preparation method and use thereof
US12359121B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 4, 2021 |
| Grant date | Jul 15, 2025 |
| Priority date | — |
| Expiry date | May 30, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC09K2211/1088
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a series of neutral fluorescent mitochondrial markers as amide derivatives, and a preparation method and use thereof. The present invention provides for the first time that neutral dyes have excellent mitochondria targeting ability after being bonded to an amide compound. The present invention solves the problems of uncertain organelle targeting ability of the existing fluorescent dyes with a neutral structure and that the neutral dye is a commercial marker for lipid droplets in cells. In the present invention, the organelle targeting ability of a fluorescent dye is regulated by creatively modifying the structure, while the optical performance of the original dye is improved; and the biological properties of the dye are obviously improved after being bonded to an amide compound. Amide compounds are cheap and readily available, which is conducive to controlling the cost of new dyes, thus having great scientific significance and commercial value.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.