Universal CAR-T cell and preparation method and use thereof

US12359169B2 · kind B2 · utility

Assignee

• SHANGHAI LONGYAO BIOTECHNOLOGY INC., LTD. · CN

Inventors

• Xuanming YANG · Shanghai, CN
• Yangxin FU · Chicago, US
• Xin Wang · Palo Alto, US
• Shengqin Ye · Shanghai, CN
• Xiaoqing Zhang · Eastvale, US

Key dates

• Filing date: Feb 25, 2022
• Grant date: Jul 15, 2025
• Expiry date: Oct 27, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16043
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a universal CAR-T cell knocking out one or more of CD3 delta, CD3 gamma, CD3 epsilon and CD3 zeta, and simultaneously introducing the HSV-TK gene. Also disclosed are a method for preparing the above-mentioned CAR-T cell, a preparation comprising the CAR-T cell, and the use of the CAR-T cell.