Method, kit and system for end labeling of nucleic acids
US12359246B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Sep 30, 2024 |
| Grant date | Jul 15, 2025 |
| Priority date | — |
| Expiry date | Sep 30, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided is a method for labeling a nucleic acid, including providing a target nucleic acid to be labeled; providing a 5′-end glycosylase to react with the target nucleic acid to create an intermediate nucleic acid having an abasic site at a 5′-end; and providing an aldehyde-reactive compound carrying a detectable label for coupling with the intermediate nucleic acid to form a labeled nucleic acid with the detectable label attached at 5′-end. Also provided are a kit and a system for labeling nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.