Single domain antibody libraries with maximized antibody developability characteristics
US12359345B2 · kind B2 · utility
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Key dates
| Filing date | Feb 17, 2023 |
| Grant date | Jul 15, 2025 |
| Priority date | — |
| Expiry date | Sep 10, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Described here are VHH antibody libraries with heavy chain variable domains framework scaffolds having complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.