Anti-tumor platinum-based drug mineralized protein nanoparticle, preparation method therefor and use thereof

US12364667B2 · kind B2 · utility

Assignee

• Soochow University · CN

Inventors

• Huabing Chen · Suzhou, CN
• Yibin DENG · Suzhou, CN
• Hong Yang · Suzhou, CN
• Hengte Ke · Suzhou, CN
• Ling Liu · Carmel, US
• Ting Li · Beijing, CN
• Tao Yang · Taizhou City, CN
• Lu Wang · Jingwei, CN

Key dates

• Filing date: Dec 22, 2021
• Grant date: Jul 22, 2025
• Expiry date: Jan 11, 2044

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Anti-tumor platinum drug mineralized protein nanoparticles and a preparation method therefor are disclosed. The anti-tumor platinum-based drug mineralized protein nanoparticles include a platinum drug and a protein. The protein is one or more selected from the group consisting of albumin, transferrin, hemoglobin, and low-density lipoprotein. The platinum drug is cisplatin, iodoplatin, bromoplatin, oxaliplatin, carboplatin, or nedaplatin. A drug loading of the anti-tumor platinum-based drug mineralized protein nanoparticles is 1% to 50%.