Patent · US Active

Process for producing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carboxylic acid

US12365679B2 · kind B2 · utility

0Cited by

4References

15Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Johannes Platzek · Berlin, DE
Kai Lovis · Düsseldorf, DE
Alba Hernandez Martin · Düsseldorf, DE
Silja Brady · Leverkusen, DE

Key dates

Filing date	Oct 12, 2020
Grant date	Jul 22, 2025
Priority date	—
Expiry date	Jul 11, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y301/01003
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for preparing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid of the formula (IIa) by optical resolution of the compound of the formula (II) using a hydrolase. The invention also relates to a process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (Ia), wherein the process comprises the optical resolution of the compound of the formula (II) using a hydrolase. The invention additionally also relates to the use of a hydrolase in a process for preparing a compound of formula (IIa). The invention further relates to the use of a hydrolase in a process for preparing a compound of formula (Ia).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.