Process to make GLP1 RA and intermediates therefor

US12365682B2 · kind B2 · utility

Assignees

• ELI LILLY AND COMPANY · US
• CHUGAI SEIYAKU KABUSHIKI KAISHA · JP

Inventors

• Ayman Allian · Grayslake, US
• Kenneth Derek Berglund · Fishers, US
• Kevin Paul COLE · Coon Rapids, US
• Ashlee Jeanette Davis · Indianapolis, US
• Molly Hess · Avon, US
• Adriana Jemison · Indianapolis, US
• Mark Steven Kerr · Indianapolis, US
• Audrey Grace Mack · Indianapolis, US
• Xavier A. Ortiz-Medina · Noblesville, US
• David Michael Remick · Indianapolis, US
• Derek Robert Starkey · Avon, US
• Radhe Krishan Vaid · West Lafayette, US
• Qiang Yang · Ellicott City, US
• Fumiki Kawagishi · Yokohama, JP
• Takashi Emura · Shizuoka, JP
• Satoshi TSUCHIYA · Shizuoka, JP
• Manabu Wadamoto · Fujisawa, JP
• Minoru Yamawaki · Yokohama, JP

Key dates

• Filing date: Sep 3, 2024
• Grant date: Jul 22, 2025
• Expiry date: Sep 3, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to the synthesis of 3-[(1S,2S)-1-[5-[(4S)-2,2-dimethyloxan-4-yl]-2-[(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methylindazol-5-yl)-2-oxoimidazol-1-yl ]-4-methyl-6,7-dihydro-4H-pyrazolo [4,3-c] pyridine-5-carbonyl] indol-1-yl]-2-methylcyclopropyl]-4H-1,2,4-oxadiazol-5-one, or a salt thereof, and related synthetic intermediate compounds.