Methods and compositions for treating cancer with ECM-affinity peptides linked to cytokines
US12365714B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Mar 5, 2019 |
| Grant date | Jul 22, 2025 |
| Priority date | — |
| Expiry date | May 8, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with a cytokine that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.