Compositions and methods for making epigenetic modifications
US12365884B2 · kind B2 · utility
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3References
22Claims
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Key dates
| Filing date | Sep 24, 2024 |
| Grant date | Jul 22, 2025 |
| Priority date | — |
| Expiry date | Sep 24, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure provides, in various embodiments, fusion proteins comprising a DNA-binding domain, a DNMT3A-binding domain, and a H3K4me0; and polynucleotides and vectors encoding one or more of the fusion proteins. The disclosure also provides, in various embodiments, gene-delivery systems, cells, compositions (e.g., pharmaceutical compositions) and kits comprising one or more of the fusion proteins polynucleotides, or vectors; methods of epigenetically modifying a genomic locus in a cell; and methods of treating a subject (e.g., a human) in need thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.