Branched lipid conjugates of siRNA for specific tissue delivery
US12365894B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Sep 16, 2020 |
| Grant date | Jul 22, 2025 |
| Priority date | — |
| Expiry date | Aug 2, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure relates to an siRNA-lipid conjugate of formula Y-L-(H)n. Y is an siRNA molecule, L is a linker covalently bonded to Y and H, each H is independently a hydrophobic chain comprising 5 to 50 carbon atoms, n is 1, 2, or 3, and linker L is bonded to the 3′ end of the sense strand of the siRNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.