Calcium channel 3.2 inhibitory peptides and uses thereof
US12365898B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Jun 29, 2022 |
| Grant date | Jul 22, 2025 |
| Priority date | — |
| Expiry date | Jun 29, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aspects of the disclosure relate to constructs comprising one or more Cav3.2 inhibitory polypeptide that blocks Cav3.2 T-type calcium channel activity and nociceptive dorsal root ganglion (DRG) neuron excitation. Also provided herein are methods for treating pain in a subject in need thereof. In particular, provided herein are methods comprising administering Cav3.2 inhibitory peptide constructs to a dorsal root ganglion of the subject, whereby expression of the Cav3.2 inhibitory polypeptides partially or fully inhibits Cav3.2 T-type calcium channel activity in the DRG.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.