Methods for mass spectrometry analysis of engineered cell compositions
US12366580B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Sep 11, 2019 |
| Grant date | Jul 22, 2025 |
| Priority date | — |
| Expiry date | Nov 18, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/03
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided herein are methods for generating a mass spectrometry (MS) profile of a sample from a cell composition, such as an engineered cell composition. In some embodiments, the mass spectrometry profile includes data based on one or more mass spectrometry analyses or techniques. Also provided herein are methods for, based on mass spectrometry profiles of one or more samples of such cell compositions: identifying a mass spectrometry (MS) profile of a genetically engineered cell composition comprising immune cells comprising a recombinant receptor by comparison to a reference mass spectrometry profile; characterizing a process for producing genetically engineered cell composition; assessing cell surface proteins of an engineered cell composition; and assessing a process for producing a genetically engineered cell composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.