Systems and methods for blood-brain barrier opening and cavitation imaging using a diagnostic imaging array

US12369880B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Elisa E. Konofagou · New York, US
• Mark Burgess · Wausau, US
• Robin Ji · New York, US
• Alec J. Batts · New York, US

Key dates

• Filing date: Feb 9, 2023
• Grant date: Jul 29, 2025
• Expiry date: Feb 9, 2043

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2007/0095
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present subject matter relates to techniques for simultaneous blood-brain barrier opening and cavitation imaging. The disclosed system can include a transducer and a processor. The transducer can be configured to generate a plurality of focused transmits and simultaneously obtain a plurality of power cavitation images. The processor can be configured to control a parameter of the focused transmits, acquire the power cavitation images between each focused transmit, and generate a cavitation map based on the power cavitation images.