Patent · US Active

Processes for the preparation of furazanobenzimidazoles and crystalline forms thereof

US12371424B2 · kind B2 · utility

0Cited by

2References

20Claims

0Family size

Assignee

Glioblastoma Foundation, Inc. · US

Inventors

Gregor Welti · Basel, CH
Markus Heubes · Kaarst, DE
David Tagliaferri · Basel, CH

Key dates

Filing date	Dec 20, 2023
Grant date	Jul 29, 2025
Priority date	—
Expiry date	Dec 20, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides processes for preparing a compound of formula I and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula II wherein each R3 independently represents a tertiary alkyl group, preferably wherein each R3 is tertiary butyl. The invention also provides intermediates useful for preparing compounds of formula I and processes for preparing these intermediates. Additionally the invention provides polymorphic forms of the dichloride salt of the compound of formula I and their use in the treatment of proliferative disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.