Antibiotic resistance-modifying tricyclic heteroaryl compounds and uses thereof
US12371429B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 15, 2019 |
| Grant date | Jul 29, 2025 |
| Priority date | — |
| Expiry date | Jun 17, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides 1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole derivative compounds and uses thereof. In particular, compounds of the invention are of the formula where n is an integer from 0-4; each of z, a1, a2, a3, a4, and a5 is independently 0 or 1, provided at least one of a1-a5 is 1; Ar1 is phenyl or a nitrogen atom containing 6-membered heteroaryl; Cyc1 is 5, 6, or 7-membered nitrogen atom containing heterocyclyl optionally containing one to three additional substituents in addition to R2a and R2b; X1 is —C(═O)—, —C(═O)—NR6—, or —SO2—NH—; each of R1a and R1c is independently C1-C6 alkylene; R1b is optionally substituted C1-C6 alkylene; X2 is O or NR6; each R1 is independently halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, —ORa, or NRbRc, where Ra hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, or a hydroxyl protecting group, and wherein each of Rb and Rc is independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, or a nitrogen protecting group; each of R2a and R2b is independently hydrogen, haloge…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.