Siderophore cephalosporin conjugates and uses thereof

US12371441B2 · kind B2 · utility

Assignee

• ARIVA MED GMBH · AT

Inventors

• Rosemarie Riedl · Wien, AT
• Susanne Paukner · Wien, AT
• Wolfgang Wicha · Trautmannsdorf, AT
• Josef Wieser · Kufstein, AT
• Klaus Thirring · Wien, AT
• Hermann Kollmann · Linz, AT

Key dates

• Filing date: Sep 4, 2020
• Grant date: Jul 29, 2025
• Expiry date: Sep 17, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of compound according to formula (I): wherein X is selected from the group consisting of CH, CCl and N, Z is selected from the group consisting of CH2COOH, CH(CH3)COOH, C(CH3)2COOH and CH2F, D is a single bond connecting A and Ar or selected from the group consisting of CO, NHCO and N(C0-6)alkyl-CO, A is selected from the group consisting of a (C1-6)alkanediyl and a (C3-6)cycloalkanediyl or, if D is N(C0)alkyl-CO, A forms a 4- to 7-membered aliphatic heterocyclic ring with the nitrogen atom of N(C0)alkyl-CO in D, and Ar is a 6-membered aromatic ring with a first hydroxyl group in para-position to D, a second hydroxyl group in meta-position to D, and with at least one electron-withdrawing element and uses thereof.