Therapeutic biologic for treatment of hepatocellular carcinoma
US12371473B2 · kind B2 · utility
0Cited by
11References
19Claims
0Family size
Assignee
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Key dates
| Filing date | Jul 20, 2022 |
| Grant date | Jul 29, 2025 |
| Priority date | — |
| Expiry date | Jun 21, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides conjugates comprising a coagulating agent conjugated to an antibody, where the antibody specifically binds an extracellular domain epitope of a mammalian PLVAP protein. These agents specifically target HCC tumors and treat the HCC. The invention also provides methods of using these conjugates, such as methods of treating HCC by administering the conjugates provided by the invention or compositions provided by the invention, such as pharmaceutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.