Method of treating cancer using anti-AV8 antibodies

US12371499B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• PFIZER INC. · US

Inventors

• Kyle Steven Niessen · Edina, US
• Dharmaraj Samuel · Dublin, US
• Charles R. Holst · San Jose, US
• Matthew Drever · Concord, US
• Dean Sheppard · Oakland, US
• Rosemary J. Akurst · Tiburon, US
• Amha Atakilit · San Francisco, US
• Dominique Meyer · Paris, FR
• Isaac J. Rondon · San Francisco, US
• Joseph Dal Porto · Los Gatos, US

Key dates

• Filing date: May 13, 2022
• Grant date: Jul 29, 2025
• Expiry date: Sep 9, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to αvβ8 integrin. The invention includes uses, and associated methods of using the antibodies.