Post-crosslinking partial degradation of amide crosslinked hydrogels
US12371513B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 28, 2021 |
| Grant date | Jul 29, 2025 |
| Priority date | — |
| Expiry date | Dec 27, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides a method of preparing a hydrogel product comprising crosslinked glycosaminoglycan molecules at a concentration Cfinal (mg/mL). The method comprising the steps of: a) crosslinking a glycosaminoglycan having a molecular weight of above 700 kDa in conditions so as to provide a glycosaminoglycan hydrogel crosslinked by amide bonds and having a Cmin (mg/mL) that is above Cfinal/2, wherein Cmin is the concentration of gel-form glycosaminoglycan in the gel when fully swollen in physiological buffer; b) subjecting the hydrogel from step a) to post-crosslinking degradation of the glycosaminoglycan backbone, thereby reducing the Cmin of the hydrogel to a value that is below Cfinal/2; and c) formulating the partially degraded hydrogel obtained from step b) to form an injectable hydrogel composition having a concentration of glycosaminoglycan molecules of Cfinal (mg/mL).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.