Bioreactor for RNA in vitro transcription

US12371646B2 · kind B2 · utility

Assignees

• CureVac Manufacturing GmbH · DE
• Tesla Automation GmbH · DE

Inventors

• Benyamin YAZDAN PANAH · Tübingen, DE
• Tilmann ROOS · Aspenhausiedlung, DE
• Martin Kunze · Rottenburg am Neckar, DE
• Felix BERTSCH · Tübingen, DE
• Aniela WOCHNER · Tübingen, DE
• Michael RAUEN · Tübingen, DE
• Philipp HOFFMANN · Tübingen, DE

Key dates

• Filing date: Jun 28, 2019
• Grant date: Jul 29, 2025
• Expiry date: Jul 28, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2563/143
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The present invention relates to a bioreactor for RNA in vitro transcription, a method for RNA in vitro transcription, a module for transcribing DNA into RNA and an automated apparatus for RNA manufacturing. Further, the use of a bioreactor for RNA in vitro transcription as described herein is part of the present invention. The present invention relates to an RNA in vitro transcription reactor designed to be operable in an automated manner under GMP-compliant conditions. In particular, said RNA in vitro transcription reactor allows repetitive use of DNA template for various RNA in vitro transcription reactions. Further, the invention relates to an apparatus for RNA manufacturing comprising (a) a module for template DNA synthesis, (b) a module for transcribing DNA into RNA comprising said RNA in vitro transcription reactor, and, optionally, (c) a module for RNA formulation.