Methods for improving the health of porcine species by targeted inactivation of CD163
US12371692B2 · kind B2 · utility
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7References
19Claims
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Key dates
| Filing date | Mar 29, 2023 |
| Grant date | Jul 29, 2025 |
| Priority date | — |
| Expiry date | Mar 29, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/124
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure relates to methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163-edited genes retain their superior properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.