Dual-responsive nanoparticles for enhanced antibacterial efficacy
US12377052B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 2021 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Oct 2, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G63/688
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are biodegradable polymers and nanoparticles comprising such polymers. The present nanoparticles deliver antibiotics to infected tissue with enhanced antibacterial efficacy. Thus, the present technology provides a nanoparticle comprising: a surface comprising one or more polysaccharides having specific binding affinity for bacteria; a core comprising a biodegradable polymer; and an antibacterial drug loaded within the core; wherein the biodegradable polymer comprises nitrogen-containing ionizable functional groups; the one or more polysaccharides having specific binding affinity for bacteria; and disulfide groups; the one or more polysaccharides are attached to the biodegradable polymer through phenyl boronic ester linkages; and the nanoparticle surface displays the polysaccharides such that the polysaccharide are available to bind to a bacterial cell surface.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.