Arterial application of low dose ethyl alcohol enables blood-brain barrier (BBB) transient opening
US12377057B2 · kind B2 · utility
Inventor
Key dates
| Filing date | Dec 24, 2024 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Dec 24, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/2818
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inducing blood-brain barrier (BBB) opening for delivery of a non-BBB permeable substance to a subject includes the steps of: administering an ethyl alcohol at 0.01%-5% v/v into an arterial bloodstream via arterial injection guided by ultrasound and inducing a homogeneous distribution of the non-BBB permeable substance in a brain parenchyma. The ethyl alcohol reaches a brain of the subject to induce a transient opening of blood-brain barrier so that the non-BBB permeable substance can penetrate the blood-brain barrier to reach the brain and its concentration can be adjusted precisely by serial dilution. The non-BBB substance includes a therapeutic agent, a diagnostic agent, or a prophylactic agent. The use of low concentration of ethyl alcohol can induce a temporary BBB opening for about 120 minutes and then the BBB can be restored to normal without causing significant harmful effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.