Lysophosphatidic acid receptor antagonist and preparation method therefor
US12377083B2 · kind B2 · utility
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Key dates
| Filing date | Jan 15, 2020 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Dec 6, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Certain compounds are lysophosphatidic acid receptor antagonists have high LPAR1 antagonist activity and selectivity, low toxicity, good metabolic stability, promising pharmaceutical development prospects, and may be used for preventing or treating LPAR1-related diseases or illnesses. The IC50 values of some of the compounds may be as low as 300 nM or below, even 50 nM or below. In addition, CC50 value range of the compounds may be as high as 200 μM or above. Furthermore, the compounds have good metabolic stability in humans, mice and rats.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.