Double-crosslinked fibrin gel, raw material composition and kit thereof, and application thereof
US12377188B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2023 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Aug 17, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/04
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a double-crosslinked fibrin gel, which is a solid hydrogel composed of a network structure with a blocking function and a network structure with an adhesion function, where the network structure with the blocking function is a three-dimensional fibrin network, and the network structure with the adhesion function is a three-dimensional photosensitive gel network; each channel of the photosensitive gel network has a group of the fibrin network inside, and each group of the fibrin network has overall continuity; on the whole, the three-dimensional fibrin network disperses disorderly throughout a surface and an interior of the solid hydrogel. The present invention further provides a raw material composition, a kit for preparing the double-crosslinked fibrin gel, and an application of the kit to prepare an in-situ rapid clotting and hemostatic material. The double-crosslinked fibrin gel prepared by the kit has a fast and efficient hemostatic effect, also can be widely applied for hemostasis of accidental trauma or a surgical wound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.