Patent · US Active

Synthesis of (S)-6-hydroxytryptophan and derivatives thereof

US12378196B2 · kind B2 · utility

0Cited by

1References

16Claims

0Family size

Assignee

Heidelberg Pharma Research GmbH · DE

Inventors

Werner Simon · Seeheim-Jugenheim, DE
Susanne Werner-Simon · Hüffelsheim, DE
Christoph Müller · Birkenau, DE

Key dates

Filing date	Dec 11, 2019
Grant date	Aug 5, 2025
Priority date	—
Expiry date	Jul 16, 2042

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01J2531/822
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.