Triazole compounds and preparation method therefor and use thereof
US12378204B2 · kind B2 · utility
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Key dates
| Filing date | Jan 15, 2020 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Nov 18, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain triazole compounds have good LPAR1 antagonistic activity and selectivity, low toxicity, and good metabolic stability, and can be used for preventing or treating the LPAR1-related disease or disorder. The IC50 value of some triazole compounds can be below 300 nM, even 50 nM. The range of CC50 of the triazole compounds can be greater than 200 μM. They also show good metabolic stability in human, fancy rats, and house mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.