Polynucleotides encoding human beta klotho antibodies or binding fragments thereof and methods of use thereof

US12378312B2 · kind B2 · utility

Assignee

• NGM Biopharmaceuticals, Inc. · US

Inventors

• Kalyani Mondal · San Mateo, US
• Betty Chan Li · Millbrae, US
• Yu Chen · Foster City, US
• Taruna Arora · Palo Alto, US
• Hugo Matern · San Mateo, US
• Wenyan Shen · Redwood City, US

Key dates

• Filing date: Jan 12, 2023
• Grant date: Aug 5, 2025
• Expiry date: Jan 12, 2043

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/66
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides binding proteins, such as antibodies or binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use such as in producing an antibody or binding fragment thereof. The present disclosure also provides vectors and cells comprising polynucleotides encoding antibodies or binding fragments thereof that bind beta klotho, including human beta klotho.