ADAM17 binding molecules and uses thereof

US12378321B2 · kind B2 · utility

Inventors

• Dimitar B. Nikolov · New York, US
• Nayanendu Saha · New York, US
• Zhongyu Zhu · Frederick, US
• Dimiter S. Dimitrov · Frederick, US
• Dorothea Robev · New York, US
• Thomas Edgeworth White · Norwalk, US

Key dates

• Filing date: Mar 7, 2020
• Grant date: Aug 5, 2025
• Expiry date: Apr 24, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides various ADAM17 binding molecules (including antibodies and fragments thereof), compositions comprising such ADAM17 binding molecules, and methods of using such ADAM17 binding molecules and compositions, for example in inhibiting binding of ADAM17 to ADAM17 substrates (such as ErbB ligands), in inhibiting the proliferation of cancer cells, and in treating cancer.