Differentiation of pluripotent stem cells using laminins LN-511, LN-521 and LN-221
US12378527B2 · kind B2 · utility
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Key dates
| Filing date | Apr 9, 2021 |
| Grant date | Aug 5, 2025 |
| Priority date | — |
| Expiry date | Aug 4, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The methods may include differentiating pluripotent stems cells on a substrate including (i) laminin-511 or 521 and (ii) laminin 221. The mature cardiomyocyte cells produced by the method may form a human heart muscle cell line for use in regenerative cardiology.
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