Resident articles for gram-level dosing

US12383495B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Carlo Giovanni Traverso · Newton, US
• Robert S. Langer · Newton, US
• Andrew Bellinger · Wellesley, US
• Tyler Grant · Arlington, US
• Malvika Verma · Cambridge, US
• Taylor Bensel · Walpole, US
• Daniel Minahan · Weymouth, US

Key dates

• Filing date: May 31, 2019
• Grant date: Aug 12, 2025
• Expiry date: Feb 18, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2210/1053
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the article includes dimensions configured for transesophageal retrieval. In some cases, the articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).