Patent · US Active

Pyrimido[5,4-b]pyrrolizin compound, optical isomer thereof, preparation method therefor and use thereof

US12384795B2 · kind B2 · utility

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1References

14Claims

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Assignee

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN

Inventors

Ao Zhang · Beijing, CN
Jian Ding · Shanghai, CN
Hua Xie · Shanghai, CN
Zilan Song · Shanghai, CN
Yu-Yi Xue · Houston, US
Li Xing · Lexington, US
Linjiang Tong · Shanghai, CN
Meiyu Geng · Shanghai, CN

Key dates

Filing date	Apr 24, 2020
Grant date	Aug 12, 2025
Priority date	—
Expiry date	Oct 2, 2042

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to a pyrimido[5,4-b]pyrrolizin compound represented by general formula I, an optical isomer thereof, a preparation method therefor, a pharmaceutical composition containing same, and a use thereof. The compound according to the present invention has good inhibitory activity on the kinase BTK at both the molecular level and the cellular level. Meanwhile, the compound also has good anti-tumor activity and pharmacokinetic properties in vivo.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.