Patent · US Active

Polymer linked multimers of guanosine-3′, 5′-cyclic monophosphates

US12384813B2 · kind B2 · utility

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1References

10Claims

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Assignee

MIRECA MEDICINES GMBH · DE

Inventors

Hans-Gottfried Genieser · Lemwerder, DE
Frank Schwede · Bremen, DE
Andreas Rentsch · Bremen, DE
Valeria Marigo · Modena, IT

Key dates

Filing date	Sep 1, 2022
Grant date	Aug 12, 2025
Priority date	—
Expiry date	Nov 13, 2042

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P37/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Embodiments of the invention are directed to new polymer linked multimeric guanosine-3′,5′-cyclic monophosphate (cGMP) analogues that modulate the cGMP-signaling system, preferably having activating properties, and more preferably being activators of cGMP dependent protein kinase (PKG), and related monomeric precursors thereof. The invention is also directed to related monomeric compounds, which may also show modulating activity and/or may serve as monomeric precursors of the multimers. The invention further relates to the use of such compounds as reagents for signal transduction research and as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and as ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.