Patent · US Active

Stabilized alpha-galactosidase and uses thereof

US12385026B2 · kind B2 · utility

0Cited by

21References

16Claims

0Family size

Assignee

Protalix Ltd. · IL

Inventors

Avidor Shulman · Rakefet, IL
Ilya Ruderfer · Carmiel, IL
Tehila BEN-MOSHE · Koranit, IL
Talia Shekhter · Netanya, IL
Yaniv Azulay · Kfar Refael, IL
Tali Kizhner · Sachnin, IL
Yoseph Shaaltiel · Beit Hillel, IL

Key dates

Filing date	Apr 8, 2022
Grant date	Aug 12, 2025
Priority date	—
Expiry date	Apr 8, 2042

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.