Patent · US Active

Conditional-siRNAS and uses thereof in treating cardiac hypertrophy

US12385041B2 · kind B2 · utility

0Cited by

18References

21Claims

0Family size

Assignees

City of Hope · US
CALIFORNIA INSTITUTE OF TECHNOLOGY · US
The General Hospital Corporation · US

Inventors

Saumya Das · Boston, US
Ane Miren Salvador Garicano · Boston, US
Si-ping Han · Pasadena, US
Lisa Scherer · Duarte, US
Julia Derogatis · Duarte, US
Robin Hu · Duarte, US
Sahil Sagar · Duarte, US
William A. Goddard, III · Pasadena, US
John J. Rossi · Goleta, US

Key dates

Filing date	Aug 10, 2018
Grant date	Aug 12, 2025
Priority date	—
Expiry date	Sep 29, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/178
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed herein are conditional siRNAs activatable by pro-hypertrophic RNA sequences and use thereof for treating conditions such as cardiac hypertrophy. The conditional siRNAs target calcineurin or HDAC2.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.