Patent · US Active

Cell-penetrating peptides

US12385042B2 · kind B2 · utility

0Cited by

0References

11Claims

0Family size

Assignee

VECTIOPEP OÜ · EE

Inventors

Piret Arukuusk · Tartu, EE
Ulo Langel · Tartu, EE
Ly Porosk · Tartu, EE

Key dates

Filing date	Jan 10, 2020
Grant date	Aug 12, 2025
Priority date	—
Expiry date	Dec 15, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3513
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides for a membrane-permeable construct for transport of cargo across a lipid membrane and subsequent delivery of cargo into cells, wherein the construct comprises a cell penetrating amino acid sequence and a fatty acid chain attached to the N terminus thereof, wherein the cell penetrating amino acid sequence comprises the sequence of SEQ ID NO: 1, or comprises a modified sequence of SEQ ID NO: 1, wherein the cell penetrating amino acid sequence comprises two or more histidine residues by substitution to its N-terminal part and/or addition to its N-terminus, and wherein the cell penetrating amino acid sequence is optionally chemically modified at the C terminus.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.