Dynamic human heavy chain antibody libraries
US12385162B2 · kind B2 · utility
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32Claims
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Key dates
| Filing date | Jan 11, 2023 |
| Grant date | Aug 12, 2025 |
| Priority date | — |
| Expiry date | Jul 19, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/569
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.